Jonathan Dickerson , Ph.D.
B.S. Wilmington College, 2003
Ph.D. University of Cincinnati, 2010
Biosketch and Research Interests
Jonathan Dickerson is a postdoctoral fellow who joined the Conn lab in September of 2010. Jon did his graduate work in the laboratory of Dr. Kim Seroogy at the University of Cincinnati. His graduate work focused on the role of a group of neurotrophic factors called neuregulins, in the injured and aged nigrostriatal system. These neuregulins showed therapeutic potential in both a young and aged neurotoxin model of Parkinson’s disease.
In the Conn laboratory, Jon plans to investigate novel therapeutic approaches such as modulation of metabotropic glutamate receptors (mGluR) for the treatment of neurodegenerative diseases. Previous work has shown that positive allosteric modulators of group III mGluRs display disease modifying properties by improving motor function in several models of Parkinson’s disease. Jon plans on using these modulators of mGluR4 in animal models of Parkinson’s disease in order to determine if they have any neuroprotective activity for the nigrostriatal system in vivo. Developing therapeutic approaches for neurodegenerative diseases that are systemically active, disease modifying, and prevent further degeneration would be highly beneficial for patients.
Carter, K., Dickerson, J., Schoepp, D.D., Reilly, M., Herring, N., Williams, J., Sallee, F.R., Sharp, J.W., and Sharp, F.R. (2004) The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis. Neuropharmacology. 47: 1135-1145.
Dickerson, J., and Sharp, F.R. (2006) Atypical antipsychotics and a Src kinase inhibitor (PP1) prevent cortical injury produced by the psychomimetic, noncompetitive NMDA receptor antagonist MK-801. Neuropsychopharmacology. 31: 1420-1430.
Dickerson, J.W., Hemmerle, A.M., Numan, S., Lundgren, K.H., and Seroogy, K.B. (2009). Decreased expression of ErbB4 and tyrosine hydroxylase mRNA and protein in the ventral midbrain of aged rats. Neuroscience. 163: 482-489.
Suidan, G.L., Dickerson, J.W., Chen, Y., Mcdole, J.R., Tripathi, P., Pirko, I., Seroogy, K.B., Johnson, A.J. (2010). CD8 T cell-mediated VEGF expression promotes CNS vascular permeability under neuro-inflammatory conditions. J. Immunol. 184: 1031-1040.
Hemmerle, A.M., Dickerson, J.W., Herring, N.R., Schaefer, T.L., Vorhees, C.V.,
Williams, M.T., and Seroogy, K.B. (2010). (±)3,4-Methylenedioxymethamphetamine (ecstasy) treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. J. Comp. Neurol. In revision.