Mark S. Moehle , Ph.D.
B.S. Neuroscience, Centenary College of Louisiana, 2010
Ph.D. Neuroscience, University of Alabama at Birmingham, 2015
Biosketch and Research Interests
Mark Moehle is a postdoctoral research fellow who joined the Conn lab in June 2015. Mark did his graduate work at the University of Alabama at Birmingham (UAB) under the mentorship of Drs. Andrew West and David Standaert studying pathogenic mechanisms behind how mutations in Leucine Rich Repeat Kinase 2 (LRRK2) lead to Parkinson disease (PD). Mutations in LRRK2 are the largest known cause of sporadic and familial PD. Because of this strong genetic link to PD, understanding how mutations in LRRK2 cause PD may lead to a novel understanding of the pathological mechanisms behind PD. Mark’s dissertation work led to the discovery that LRRK2 is an important modulator of some specific functions of immune cells both in the brain and the peripheral immune system. This discovery, along with work from the Standaert and West Labs, has led to an emerging hypothesis that PD may be caused or exacerbated by inflammation.
In the Conn lab, Mark will be extending his work on pathological mechanisms behind PD by pursuing novel pharmacological treatments for PD and other movement disorders. Mark will be utilizing recently developed allosteric modulators of GPCRs in conjunction with disease relevant mouse models to understand the therapeutic potential of GPCR modulation in movement disorders.
For a full list of Mark’s publications, please see here (http://www.ncbi.nlm.nih.gov/pubmed/?term=Moehle%20MS%5BAuthor%5D&cauthor=true&cauthor_uid=26078453)